Lifespan: Why We Age--And Why We Don't Have to by David A. Sinclair (English) Ha

Description: Lifespan by David A. Sinclair, Matthew D. Laplante From an acclaimed Harvard professor and one of TIMEs most influential people comes a paradigm-shifting book that shows how almost everything people think they know about aging is wrong. He offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description A NEW YORK TIMES BESTSELLER "Brilliant and enthralling." --The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Times most influential people. Its a seemingly undeniable truth that aging is inevitable. But what if everything weve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: "Aging is a disease, and that disease is treatable." This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclairs own lab at Harvard--that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat--that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. Author Biography David Sinclair, PhD, AO, is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as "one of the 100 most influential people in the world" and top fifty most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than thirty-five awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. To learn more, visit LifespanBook.com and follow him on Twitter @DavidASinclair. Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante. Review "Brilliant and enthralling." --Wall Street Journal"Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to frontlines of incredible breakthroughs. What could be more valuable than an extended health lifespan? Enjoy this must read masterpiece!"--Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold"Lifespan is the book we have been waiting for. It transcends everything we know about aging and longevity--a combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the roadmap on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger."--Naomi Whittel, New York Times bestselling author of Glow15"A tour de force. Sinclairs book, and his lifes work ranks with humanitys greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison. Lifespan is a groundbreaking literary triptych that expertly combines the science of living longer, a practical checklist to unleash our inner potential for healthy longevity, and a brilliant philosophical, policy and ethical synthesis. A masterpiece."--Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio"A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer."--Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure"For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read."--Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimers"I have had the pleasure of knowing Dr. David Sinclair and following his groundbreaking research into the causes and reversal of aging for many years. In Lifespan, David takes us on an entertainingly wild ride into both the authors fascinating personal journey of discovery and his seminal research into why we age. But more importantly, he provides us with the everyday tools that we can all use to stop what he now calls the disease of aging.. . . You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!"--Steven R Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute"I have written about the brilliant work of David Sinclair for over fifteen years and have watched his lifes mission of using science to slow the scourge of old age and dying move from the outer edge to more mainstream biology (hes still pushing boundaries!) as his careful work in the lab has steadily shed light on how the mechanisms of aging work in humans and in other organisms. In Lifespan, the full force of his optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. I was charmed and delighted by his skill at blending his own lifes narrative and others with clear and levelheaded explanations of some very complex and emerging science. Im hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century."--David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion"If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclairs new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant."--Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author"Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclairs vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds. Lifespan is boldly leading the way."--Jason Fung, MD, author of The Diabetes Code and The Obesity Code"In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read."--William W. Li, MD, New York Times bestselling author of Eat to Beat Disease"Stepping on the moon changed humanity. In Lifespan, Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. If you can put your deepest beliefs aside, this will be the most important book you will ever read. The author is bold, the science is profound, and our future is here."--Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals"Lifespan is entertaining and fast-paced--a whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (The Demented Pianist, A Better Pill to Swallow), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point."-- "Nature Journal" Review Quote "This is the most visionary book about aging I have ever read. Seize the day--and seize this book!" Excerpt from Book Lifespan INTRODUCTION A GRANDMOTHERS PRAYER I GREW UP ON THE edge of the bush. In figurative terms, my backyard was a hundred-acre wood. In literal terms, it was much bigger than that. It went on as far as my young eyes could see, and I never grew tired of exploring it. I would hike and hike, stopping to study the birds, the insects, the reptiles. I pulled things apart. I rubbed the dirt between my fingers. I listened to the sounds of the wild and tried to connect them to their sources. And I played. I made swords from sticks and forts from rocks. I climbed trees and swung on branches and dangled my legs over steep precipices and jumped off of things that I probably shouldnt have jumped off. I imagined myself as an astronaut on a distant planet. I pretended to be a hunter on safari. I lifted my voice for the animals as though they were an audience at the opera house. "Coooeey!" I would holler, which means "Come here" in the language of the Garigal people, the original inhabitants. I wasnt unique in any of this, of course. There were lots of kids in the northern suburbs of Sydney who shared my love of adventure and exploration and imagination. We expect this of children. We want them to play this way. Until, of course, theyre "too old" for that sort of thing. Then we want them to go to school. Then we want them to go to work. To find a partner. To save up. To buy a house. Because, you know, the clock is ticking. My grandmother was the first person to tell me that it didnt have to be that way. Or, I guess, she didnt tell me so much as show me. She had grown up in Hungary, where she spent Bohemian summers swimming in the cool waters of Lake Balaton and hiking in the mountains of its northern shore at a holiday resort that catered to actors, painters, and poets. In the winter months, she helped run a hotel in the Buda Hills before the Nazis took it over and converted it to the central command of the Schutzstaffel, or "SS." A decade after the war, in the early days of the Soviet occupation, the Communists began to shut down the borders. When her mother tried to cross illegally into Austria, she was caught, arrested, and sentenced to two years in jail and died shortly after. During the Hungarian Uprising in 1956, my grandmother wrote and distributed anti-Communist newsletters in the streets of Budapest. After the revolution was crushed, the Soviets began arresting tens of thousands of dissidents, and she fled to Australia with her son, my father, reasoning that it was the furthest they could get from Europe. She never set foot in Europe again, but she brought every bit of Bohemia with her. She was, I have been told, one of the first women to sport a bikini in Australia and got chased off Bondi Beach because of it. She spent years living in New Guinea--which even today is one of the most intensely rugged places on our planet--all by herself. Though her bloodline was Ashkenazi Jew and she had been raised a Lutheran, my grandmother was a very secular person. Our equivalent of the Lords Prayer was the English author Alan Alexander Milnes poem "Now We Are Six," which ends: But now I am six, Im as clever as clever. So I think Ill be six now for ever and ever. She read that poem to my brother and me again and again. Six, she told us, was the very best age, and she did her damnedest to live life with the spirit and awe of a child of that age. Even when we were very young, my grandmother didnt want us to call her "grandmother." Nor did she like the Hungarian term, "nagymama," or any of the other warm terms of endearment such as "bubbie," "grandma," and "nana." To us boys, and everyone else, she was simply Vera. Vera taught me to drive, swerving and swaying across all of the lanes, "dancing" to whatever music was on the cars radio. She told me to enjoy my youth, to savor the feeling of being young. Adults, she said, always ruined things. Dont grow up, she said. Never grow up. Well into her 60s and 70s, she was still what we call "young at heart," drinking wine with friends and family, eating good food, telling great stories, helping the poor, sick, and less fortunate, pretending to conduct symphonies, laughing late into the night. By just about anyones standard, thats the mark of a "life well lived." But yes, the clock was ticking. By her mid-80s, Vera was a shell of her former self, and the final decade of her life was hard to watch. She was frail and sick. She still had enough wisdom left to insist that I marry my fianc Details ISBN1501191977 Author Matthew D. Laplante Short Title LIFESPAN Pages 432 Publisher Atria Books Language English ISBN-10 1501191977 ISBN-13 9781501191978 Format Hardcover DEWEY 570 Year 2019 Publication Date 2019-09-10 Imprint Atria Books Subtitle Why We Age--And Why We Dont Have to Illustrations Illustrations, unspecified Audience General UK Release Date 2019-09-10 We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:125298087;

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